Notes on Exacerbations
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Viral model of COPD exacerbation
- Give patients with COPD rhinovirus and measure lung function, sputum neutrophils, bacterial counts etc in comparison to non-obstructed control patients.
- Rhinovirus infection worsened breathlessness, post bronchodilator peak flows, sputum neutrophilia and caused secondary increase in bacterial colonisation and the degradation of antimicrobial peptides (see below)