Connective tissue diseases

  Basic Physician Training MCQs
  • About
  • Written
    • Respiratory Medicine
    • Medical Oncology >
      • Colorectal Cancer
      • Lung Cancer
      • Urogenital Cancers
      • Emergencies
      • Melanoma
      • Breast
    • Haematology >
      • Anaemia
      • Coagulation
      • Malignancy
    • Cardiology >
      • General Cardiology
      • Coronary Artery Disease
      • Heart Failure
      • Valvular Heart Disease
      • Arrhythmia
    • Endocrinology >
      • General Endocrinology
      • Reproduction
      • Pituitary
      • Diabetes
    • Clinical Immunology
    • Clinical Toxicology
    • Genetics
    • Geriatrics
    • General Medicine
    • Statistics
    • Gastroenterology >
      • Pancreas
      • Inflammatory Bowel Disease
      • Oesophageal Diseases
      • Stomach and Small Intestine
      • Liver
    • Infectious Diseases >
      • Viruses
      • Bacteria
      • Parasites
      • Fungus
    • Neurology >
      • Anatomy
      • Nystagmus
      • Myopathies
      • Stroke
      • Neurodegenerative Disorders
      • Neuropathy
    • Nephrology >
      • Glomerulonephritis
      • General Nephrology
      • Chronic Kidney Disease
    • Psychiatry
    • Palliative Care
    • Pharmacology
    • Rheumatology >
      • Rheumatoid Arthritis
      • Connective Tissue Diseases
      • Spondyloarthropathies
      • Crystal Arthropathy
  • Clinical
    • Short Cases >
      • Haematology
      • Endocrine
      • Neurology
      • Rheumatology
      • Renal
      • Gastroenterology
      • Cardiology
      • Respiratory
    • Long Cases >
      • Addiction & Psychiatry
      • Cardiology
      • Endocrinology
      • Geriatrics
      • Gastroenterology
      • Renal
      • Haematology
      • Infectious Diseases
      • Oncology
      • Rheumatology
      • Respiratory
      • Neurology
      • Set pieces
  • Medical Students
  • Respiratory
    • Asthma >
      • Acute Exacerbation
    • COPD >
      • Exacerbations
    • Lung Cancer >
      • Targeted therapy
    • Tobacco
    • Questionnaires
Question 1
Which of the following pathophysiological hallmarks differentiate giant cell arteritis from polymyalgia rheumatica?

(A) dendritic cell involvement
(B) Th1/ INF-beta/ IL-12 response
(C) Th17/ IL17/ IL-6 response
(D) Raised ESR
(E) Raised CRP

B: Giant cell arteritis tends to have both Th1 and Th17 type responses, with only the later being steroid sensitive and suppressible. PMR tends to involve Th17 response, being exquisitely steroid sensitive. N Engl J Med 2014; 371:50-57, PEP lectures 2014

Question 2
Which of the following is NOT a pathological abnormality that occurs in giant cell arteritis

(A) involvement of the internal elastic lamina
(B) predominant dendritic cell response
(C) smooth muscle and fibroblast proliferation
(D) granulomatous inflammation
(E) predominant Th2 driven inflammatory response

E: N Engl J Med 2014; 371:50-57

Question 3
Which HLA allele is associated with a poorer visual symptom prognosis in giant cell arteritis?

(A) HLA B5
(B) HLA DR2/ DQ8
(C) HLA DQ1
(D) HLA B57
(E) HLA DRB1*04

E: N Engl J Med 2014; 371:50-57

​Question 4

Which of the following antibodies is associated with scleroderma renal crisis?

(A) centromere
(B) scl70
(C) U3-RNP
(D) ANA
(E) RNA-polymerase III

E: Anti-centromere is associated with limited scleroderma, having a better prognosis and less ILD. Anti Scl70 is associated with diffuse scleroderma and ILD. U3-RNP is associated with SLE, mixed connective tissue disease and pulmonary arterial hypertension in an African-American population. RNA-polymerase III is associated with diffuse cutaneous involvement and scleroderma renal crisis. BMJ 2015;351:h5079

Question 5
Which of the following is NOT associated with RNA-polymerase III antibodies?

(A) Diffuse scleroderma
(B) Megaloblastic anaemia
(C) Iron deficiency anaemia
(D) scleroderma renal crisis
(E) gastric astral vascular ectasia

B: RNA polymerase is associated with GAVE, which may predispose to iron deficiency anaemia in patients with scleroderma. J Rheumatol 2014;41:99-105

Question 6
Which of the following antibodies are NOT found in dermatomyositis or polymyositis?

(A) Anti-SRP
(B) Anti-Jo1
(C) Anti-OJ
(D) Anti-CJ

(E) Anti-Mi2

D: Anti-Sdnthetase antibodies are the most common antibodies found and include Anti-Jo1, Anti-PL12, anti-PL7, Anti-OJ and anti-EJ. Anti-Mi2 is related to dermatomyositis and has a good prognosis. The most common anti-synthetase antibody is anti-Jo-1, which targets histidyl-tRNA synthetase. Autoimmun Rev2014;13:883-91

​Question 7
The following is a picture of a patient's hand, courtesy of sticksite.com. 
Picture
Which of the following medications does not have evidence to support its use primary for this treatment?

(A) Nitrates
(B) Sildafenil
(C) Amlodipine
(D) Fluoxetine
(E) Hydroxychloroquine

E: Lancet 1995; 345:1378. - evidence for SSRIs

Question 8
Rheumatoid factor is associated with both connective tissue disease and non-connective tissue disease. Which of the following non connective tissue diseases is rheumatoid factor LEAST found in?

(A) Hepatitis B
(B) Hepatitis C
(C) TB
(D) Silicosis
(E) Cryoglobulinaemia

B: Am J Med 1991 91:528

​
Powered by Create your own unique website with customizable templates.
  • About
  • Written
    • Respiratory Medicine
    • Medical Oncology >
      • Colorectal Cancer
      • Lung Cancer
      • Urogenital Cancers
      • Emergencies
      • Melanoma
      • Breast
    • Haematology >
      • Anaemia
      • Coagulation
      • Malignancy
    • Cardiology >
      • General Cardiology
      • Coronary Artery Disease
      • Heart Failure
      • Valvular Heart Disease
      • Arrhythmia
    • Endocrinology >
      • General Endocrinology
      • Reproduction
      • Pituitary
      • Diabetes
    • Clinical Immunology
    • Clinical Toxicology
    • Genetics
    • Geriatrics
    • General Medicine
    • Statistics
    • Gastroenterology >
      • Pancreas
      • Inflammatory Bowel Disease
      • Oesophageal Diseases
      • Stomach and Small Intestine
      • Liver
    • Infectious Diseases >
      • Viruses
      • Bacteria
      • Parasites
      • Fungus
    • Neurology >
      • Anatomy
      • Nystagmus
      • Myopathies
      • Stroke
      • Neurodegenerative Disorders
      • Neuropathy
    • Nephrology >
      • Glomerulonephritis
      • General Nephrology
      • Chronic Kidney Disease
    • Psychiatry
    • Palliative Care
    • Pharmacology
    • Rheumatology >
      • Rheumatoid Arthritis
      • Connective Tissue Diseases
      • Spondyloarthropathies
      • Crystal Arthropathy
  • Clinical
    • Short Cases >
      • Haematology
      • Endocrine
      • Neurology
      • Rheumatology
      • Renal
      • Gastroenterology
      • Cardiology
      • Respiratory
    • Long Cases >
      • Addiction & Psychiatry
      • Cardiology
      • Endocrinology
      • Geriatrics
      • Gastroenterology
      • Renal
      • Haematology
      • Infectious Diseases
      • Oncology
      • Rheumatology
      • Respiratory
      • Neurology
      • Set pieces
  • Medical Students
  • Respiratory
    • Asthma >
      • Acute Exacerbation
    • COPD >
      • Exacerbations
    • Lung Cancer >
      • Targeted therapy
    • Tobacco
    • Questionnaires