Crystal Arthropathy

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Question 1
Which of the following anti-gout medications works by inhibiting the URAT-1 transporter and GLUT9 transporter?

(A) Probenecid
(B) Feboxustat
(C) Allopurinol
(D) Rasburicase
(E) Anakinra

A: URAT-1 is an organic anion exchanger found on the apical surfaces of the proximal tubule, whilst GLUT-9 is a transporter found on the basolateral surface. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36)

Question 2
What is an appropriate pharmacological strategy when using xanthine oxidase inhibitors in the prophylaxis treatment of gout without tophi?

(A) Maintain serum uric acid <0.3 mM
(B) Maintain serum uric acid <0.36 mM
(C) Increase the allopurinol dose to a maximum after slow up-titration irrespective of the serum urate level
(D) Reduce the number of acute gout exacerbations to <3 per year
(E) Up-titration based on renal function rather than tolerability to achieve serum uric acid targets

B: If there are no tophi, the medical journal of australia recommends serum uric acid levels be maintained <0.36mM. Up-titration to a maximum level needed to suppress uric acid levels <0.36 should be based on tolerability rather than renal function. Serum uric acid levels should be maintained less than <0.3 mM if there is the presence of tophi. Med J Aust 2015; 203 (2): 86-88.
​
Question 3
Which of the following joints is closely associated with obesity and osteoarthritis?

(A) Subtalar
(B) Hand
​(C) Knee
(D) Hip
(E) Elbow

C: Knee has the greatest association, then hand then hip! Uptodate 2016


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  • About
  • Written
    • Respiratory Medicine
    • Medical Oncology >
      • Colorectal Cancer
      • Lung Cancer
      • Urogenital Cancers
      • Emergencies
      • Melanoma
      • Breast
    • Haematology >
      • Anaemia
      • Coagulation
      • Malignancy
    • Cardiology >
      • General Cardiology
      • Coronary Artery Disease
      • Heart Failure
      • Valvular Heart Disease
      • Arrhythmia
    • Endocrinology >
      • General Endocrinology
      • Reproduction
      • Pituitary
      • Diabetes
    • Clinical Immunology
    • Clinical Toxicology
    • Genetics
    • Geriatrics
    • General Medicine
    • Statistics
    • Gastroenterology >
      • Pancreas
      • Inflammatory Bowel Disease
      • Oesophageal Diseases
      • Stomach and Small Intestine
      • Liver
    • Infectious Diseases >
      • Viruses
      • Bacteria
      • Parasites
      • Fungus
    • Neurology >
      • Anatomy
      • Nystagmus
      • Myopathies
      • Stroke
      • Neurodegenerative Disorders
      • Neuropathy
    • Nephrology >
      • Glomerulonephritis
      • General Nephrology
      • Chronic Kidney Disease
    • Psychiatry
    • Palliative Care
    • Pharmacology
    • Rheumatology >
      • Rheumatoid Arthritis
      • Connective Tissue Diseases
      • Spondyloarthropathies
      • Crystal Arthropathy
  • Clinical
    • Short Cases >
      • Haematology
      • Endocrine
      • Neurology
      • Rheumatology
      • Renal
      • Gastroenterology
      • Cardiology
      • Respiratory
    • Long Cases >
      • Addiction & Psychiatry
      • Cardiology
      • Endocrinology
      • Geriatrics
      • Gastroenterology
      • Renal
      • Haematology
      • Infectious Diseases
      • Oncology
      • Rheumatology
      • Respiratory
      • Neurology
      • Set pieces
  • Medical Students
  • Respiratory
    • Asthma >
      • Acute Exacerbation
    • COPD >
      • Exacerbations
    • Lung Cancer >
      • Targeted therapy
    • Tobacco
    • Questionnaires